Detailed information of TA system TA025018

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2631973..2632529
• Replicon: chromosome
• Accession: NC_014836
• Organism: Desulfurispirillum indicum S5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E6W3N4
• Locus tag: SELIN_RS14920
• Protein ID: WP_013506792.1
• Coordinates: 2632218..2632529 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E6W4M2
• Locus tag: SELIN_RS12290
• Protein ID: WP_013506968.1
• Coordinates: 2631973..2632230 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SELIN_RS12270	2627961..2628155	+	195	WP_013506964.1	DUF2007 domain-containing protein	-
SELIN_RS12275	2628588..2629334	+	747	WP_013506965.1	DUF1016 family protein	-
SELIN_RS12280	2629601..2630710	-	1110	WP_013506966.1	transposase	-
SELIN_RS12285	2630710..2631621	-	912	WP_013506967.1	site-specific integrase	-
SELIN_RS12290	2631973..2632230	+	258	WP_013506968.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SELIN_RS14920	2632218..2632529	+	312	WP_013506792.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SELIN_RS12295	2633406..2634230	+	825	WP_013506969.1	PDZ domain-containing protein	-
SELIN_RS12300	2634318..2635073	+	756	WP_013506970.1	HNH endonuclease	-
SELIN_RS12305	2635331..2635588	+	258	WP_013506793.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
SELIN_RS12310	2635576..2635887	+	312	WP_013506792.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11755.57 Da
• Isoelectric Point: 4.5716

>T25018 WP_013506792.1 NC_014836:2632218-2632529 [Desulfurispirillum indicum S5]
VAEIVWTDPALDQLEEIADYIALDKPEAAAGLVKKIFSTVDRLGQFPDSGHVPPEIPGSIYREISVRPCRIFYRQDKGVV
FIVHVMREEMLLRKFLLDEELNS

Nucleotide

• Length: 312 bp

>T25018 NC_014836:2632218-2632529 [Desulfurispirillum indicum S5]
GTGGCTGAAATAGTATGGACGGATCCCGCACTGGATCAACTGGAAGAAATCGCAGATTACATCGCGTTGGATAAGCCGGA
AGCTGCCGCAGGGCTTGTTAAGAAAATATTTTCAACCGTGGATCGGCTTGGGCAGTTTCCGGATTCGGGACATGTCCCCC
CCGAGATTCCAGGCTCGATATATCGTGAAATTTCTGTCAGGCCATGTCGAATATTTTACCGTCAAGACAAGGGTGTGGTT
TTCATTGTTCACGTCATGAGGGAAGAAATGTTGTTACGTAAATTTCTTCTGGACGAGGAGTTGAACAGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9862.41 Da
• Isoelectric Point: 9.6237

>AT25018 WP_013506968.1 NC_014836:2631973-2632230 [Desulfurispirillum indicum S5]
MKVELVTNLKRQATRILADLHESKEAVLITEHGQPSAYLVDVQDYEFMQRRLALLEGLSKGERAILEGRTTSHEKAKERM
QKWLK

Nucleotide

• Length: 258 bp

>AT25018 NC_014836:2631973-2632230 [Desulfurispirillum indicum S5]
ATGAAAGTTGAGCTTGTAACCAATCTAAAGCGTCAAGCGACAAGAATTCTTGCTGATCTGCATGAGAGCAAGGAAGCGGT
CCTGATCACAGAACACGGCCAGCCATCCGCTTACCTGGTCGATGTTCAGGATTACGAATTCATGCAGCGCAGGCTGGCGC
TGCTGGAAGGATTGTCCAAGGGAGAAAGGGCCATTCTGGAGGGCAGAACGACCTCCCATGAAAAGGCCAAAGAGCGGATG
CAAAAGTGGCTGAAATAG

Structures

Toxin

• AlphaFold DB: E6W3N4

Antitoxin

• AlphaFold DB: E6W4M2