Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4855853..4856369 Replicon chromosome
Accession NZ_CP100106
Organism Klebsiella pneumoniae strain HSKP107

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NIL13_RS23540 Protein ID WP_004178374.1
Coordinates 4855853..4856137 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NIL13_RS23545 Protein ID WP_002886901.1
Coordinates 4856127..4856369 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL13_RS23515 (4851337) 4851337..4851600 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
NIL13_RS23520 (4851730) 4851730..4851903 + 174 WP_032408826.1 hypothetical protein -
NIL13_RS23525 (4851906) 4851906..4852649 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NIL13_RS23530 (4853006) 4853006..4855144 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NIL13_RS23535 (4855385) 4855385..4855849 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NIL13_RS23540 (4855853) 4855853..4856137 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL13_RS23545 (4856127) 4856127..4856369 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NIL13_RS23550 (4856447) 4856447..4858357 - 1911 WP_004178373.1 PRD domain-containing protein -
NIL13_RS23555 (4858380) 4858380..4859534 - 1155 WP_004178372.1 lactonase family protein -
NIL13_RS23560 (4859601) 4859601..4860341 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T250179 WP_004178374.1 NZ_CP100106:c4856137-4855853 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250179 WP_002886901.1 NZ_CP100106:c4856369-4856127 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References