Detailed information of TA system TA025017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2427324..2427880
• Replicon: chromosome
• Accession: NC_014836
• Organism: Desulfurispirillum indicum S5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E6W3N4
• Locus tag: SELIN_RS11335
• Protein ID: WP_013506792.1
• Coordinates: 2427324..2427635 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E6W3N5
• Locus tag: SELIN_RS11340
• Protein ID: WP_013506793.1
• Coordinates: 2427623..2427880 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SELIN_RS11315	2422599..2423813	-	1215	WP_013505421.1	ISL3 family transposase	-
SELIN_RS11320	2424103..2426091	+	1989	WP_013506790.1	methyl-accepting chemotaxis protein	-
SELIN_RS11325	2426120..2426701	-	582	WP_013506791.1	transglutaminase family protein	-
SELIN_RS11335	2427324..2427635	-	312	WP_013506792.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SELIN_RS11340	2427623..2427880	-	258	WP_013506793.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SELIN_RS15140	2430037..2430213	-	177	WP_013506795.1	hypothetical protein	-
SELIN_RS11360	2430523..2431449	+	927	WP_041726091.1	tRNA glutamyl-Q(34) synthetase GluQRS	-
SELIN_RS11365	2431549..2432571	+	1023	WP_041726092.1	NAD-dependent epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2429002..2429490	488
	-	inside	Integron	-	-	2427272..2428628	1356

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11755.57 Da
• Isoelectric Point: 4.5716

>T25017 WP_013506792.1 NC_014836:c2427635-2427324 [Desulfurispirillum indicum S5]
VAEIVWTDPALDQLEEIADYIALDKPEAAAGLVKKIFSTVDRLGQFPDSGHVPPEIPGSIYREISVRPCRIFYRQDKGVV
FIVHVMREEMLLRKFLLDEELNS

Nucleotide

• Length: 312 bp

>T25017 NC_014836:c2427635-2427324 [Desulfurispirillum indicum S5]
GTGGCTGAAATAGTATGGACGGATCCCGCACTGGATCAACTGGAAGAAATCGCAGATTACATCGCGTTGGATAAGCCGGA
AGCTGCCGCAGGGCTTGTTAAGAAAATATTTTCAACCGTGGATCGGCTTGGGCAGTTTCCGGATTCGGGACATGTCCCCC
CCGAGATTCCAGGCTCGATATATCGTGAAATTTCTGTCAGGCCATGTCGAATATTTTACCGTCAAGACAAGGGTGTGGTT
TTCATTGTTCACGTCATGAGAGAAGAAATGTTGTTACGTAAATTTCTTCTGGACGAGGAGTTGAACAGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9834.40 Da
• Isoelectric Point: 9.5940

>AT25017 WP_013506793.1 NC_014836:c2427880-2427623 [Desulfurispirillum indicum S5]
MKVELVTNLKRQATKILADLHESKEAVLITEHGQPSAYLVDVQDYEFMQRRLALLEGLSKGERAILEGRTTSHEKAKERM
QKWLK

Nucleotide

• Length: 258 bp

>AT25017 NC_014836:c2427880-2427623 [Desulfurispirillum indicum S5]
ATGAAAGTTGAGCTTGTAACCAATCTAAAGCGTCAAGCGACAAAAATTCTTGCTGATCTGCATGAGAGCAAGGAAGCGGT
CCTGATCACAGAACACGGCCAGCCATCCGCTTACCTGGTCGATGTTCAGGATTACGAATTCATGCAGCGCAGGCTGGCGC
TGCTGGAAGGATTGTCCAAGGGAGAAAGGGCCATTCTGGAGGGCAGAACGACCTCCCATGAAAAGGCCAAAGAGCGGATG
CAAAAGTGGCTGAAATAG

Structures

Toxin

• AlphaFold DB: E6W3N4

Antitoxin

• AlphaFold DB: E6W3N5