Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 38371..39014 Replicon plasmid pHSKP33-1
Accession NZ_CP100103
Organism Klebsiella pneumoniae strain HSKP33

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NIL14_RS26280 Protein ID WP_014386165.1
Coordinates 38598..39014 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NIL14_RS26275 Protein ID WP_032408893.1
Coordinates 38371..38601 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL14_RS26250 (NIL14_26235) 33444..34427 - 984 WP_001471744.1 NAD(P)H-quinone oxidoreductase -
NIL14_RS26255 (NIL14_26240) 34446..35594 - 1149 WP_014386168.1 ABC transporter ATP-binding protein -
NIL14_RS26260 (NIL14_26245) 35765..36922 - 1158 WP_032408895.1 acetylornithine deacetylase -
NIL14_RS26265 (NIL14_26250) 36938..37612 - 675 WP_014386166.1 DUF1028 domain-containing protein -
NIL14_RS26270 (NIL14_26255) 37617..38051 - 435 WP_000103648.1 RidA family protein -
NIL14_RS26275 (NIL14_26260) 38371..38601 + 231 WP_032408893.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIL14_RS26280 (NIL14_26265) 38598..39014 + 417 WP_014386165.1 PIN domain-containing protein Toxin
NIL14_RS26285 (NIL14_26270) 39337..40303 + 967 Protein_53 IS5-like element IS903B family transposase -
NIL14_RS26290 (NIL14_26275) 40483..40857 - 375 WP_032408891.1 hypothetical protein -
NIL14_RS26295 (NIL14_26280) 40913..41239 - 327 WP_004152639.1 hypothetical protein -
NIL14_RS26300 (NIL14_26285) 41236..41964 - 729 WP_014386162.1 plasmid SOS inhibition protein A -
NIL14_RS26305 (NIL14_26290) 41961..42392 - 432 WP_264237933.1 conjugation system SOS inhibitor PsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..175328 175328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15127.44 Da        Isoelectric Point: 7.8841

>T250164 WP_014386165.1 NZ_CP100103:38598-39014 [Klebsiella pneumoniae]
MTKTYMLDTNICSYIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGAIGKRASPRHVQLVDAFCARLDAILAWDRA
AVDATTEVKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVAGLTFEDWVQ

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8854.89 Da        Isoelectric Point: 4.5112

>AT250164 WP_032408893.1 NZ_CP100103:38371-38601 [Klebsiella pneumoniae]
MRTVSVFRNGNNRAIRLPRDLDFDGVNELEIIREGDTLILRPVKPSWSSFRQEEKADADFMAERENVVSDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References