Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3765531..3766188 Replicon chromosome
Accession NZ_CP100102
Organism Klebsiella pneumoniae strain HSKP33

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NIL14_RS18205 Protein ID WP_002916310.1
Coordinates 3765778..3766188 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NIL14_RS18200 Protein ID WP_002916312.1
Coordinates 3765531..3765797 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL14_RS18175 (3760687) 3760687..3762120 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
NIL14_RS18180 (3762239) 3762239..3762967 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NIL14_RS18185 (3763017) 3763017..3763328 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NIL14_RS18190 (3763492) 3763492..3764151 + 660 WP_002916317.1 hemolysin III family protein -
NIL14_RS18195 (3764302) 3764302..3765285 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
NIL14_RS18200 (3765531) 3765531..3765797 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NIL14_RS18205 (3765778) 3765778..3766188 + 411 WP_002916310.1 protein YgfX Toxin
NIL14_RS18210 (3766195) 3766195..3766716 - 522 WP_004144730.1 flavodoxin FldB -
NIL14_RS18215 (3766817) 3766817..3767713 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NIL14_RS18220 (3767736) 3767736..3768449 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIL14_RS18225 (3768455) 3768455..3770188 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250158 WP_002916310.1 NZ_CP100102:3765778-3766188 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250158 WP_002916312.1 NZ_CP100102:3765531-3765797 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References