Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2529343..2531024 Replicon chromosome
Accession NZ_CP100102
Organism Klebsiella pneumoniae strain HSKP33

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag NIL14_RS12185 Protein ID WP_004178299.1
Coordinates 2529343..2530260 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NIL14_RS12190 Protein ID WP_004177809.1
Coordinates 2530266..2531024 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL14_RS12165 (2524649) 2524649..2526169 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NIL14_RS12170 (2526166) 2526166..2527164 + 999 WP_002885172.1 ribose ABC transporter permease -
NIL14_RS12175 (2527195) 2527195..2528136 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NIL14_RS12180 (2528211) 2528211..2529218 + 1008 WP_004178300.1 carbohydrate kinase family protein -
NIL14_RS12185 (2529343) 2529343..2530260 - 918 WP_004178299.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NIL14_RS12190 (2530266) 2530266..2531024 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NIL14_RS12195 (2531110) 2531110..2531838 - 729 WP_004178298.1 response regulator transcription factor -
NIL14_RS12200 (2532111) 2532111..2534258 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
NIL14_RS12205 (2534255) 2534255..2534398 - 144 WP_022631365.1 hypothetical protein -
NIL14_RS12210 (2534720) 2534720..2535406 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34649.06 Da        Isoelectric Point: 5.4707

>T250154 WP_004178299.1 NZ_CP100102:c2530260-2529343 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT250154 WP_004177809.1 NZ_CP100102:c2531024-2530266 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References