Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2373649..2374165 Replicon chromosome
Accession NZ_CP100102
Organism Klebsiella pneumoniae strain HSKP33

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NIL14_RS11395 Protein ID WP_004178374.1
Coordinates 2373649..2373933 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NIL14_RS11400 Protein ID WP_002886901.1
Coordinates 2373923..2374165 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL14_RS11370 (2369133) 2369133..2369396 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
NIL14_RS11375 (2369526) 2369526..2369699 + 174 WP_032408826.1 hypothetical protein -
NIL14_RS11380 (2369702) 2369702..2370445 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NIL14_RS11385 (2370802) 2370802..2372940 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NIL14_RS11390 (2373181) 2373181..2373645 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NIL14_RS11395 (2373649) 2373649..2373933 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL14_RS11400 (2373923) 2373923..2374165 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NIL14_RS11405 (2374243) 2374243..2376153 - 1911 WP_004178373.1 PRD domain-containing protein -
NIL14_RS11410 (2376176) 2376176..2377330 - 1155 WP_004178372.1 lactonase family protein -
NIL14_RS11415 (2377397) 2377397..2378137 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T250153 WP_004178374.1 NZ_CP100102:c2373933-2373649 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250153 WP_002886901.1 NZ_CP100102:c2374165-2373923 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References