Detailed information of TA system TA025015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1065394..1065928
• Replicon: chromosome
• Accession: NC_014836
• Organism: Desulfurispirillum indicum S5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E6W358
• Locus tag: SELIN_RS05060
• Protein ID: WP_013505602.1
• Coordinates: 1065394..1065693 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E6W359
• Locus tag: SELIN_RS05065
• Protein ID: WP_013505603.1
• Coordinates: 1065683..1065928 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SELIN_RS05035	1060699..1061553	+	855	WP_083805929.1	RHS repeat-associated core domain-containing protein	-
SELIN_RS15090	1061633..1062169	+	537	WP_013505597.1	hypothetical protein	-
SELIN_RS15095	1062249..1062791	+	543	WP_013505598.1	hypothetical protein	-
SELIN_RS05045	1062970..1063443	+	474	WP_013505599.1	hypothetical protein	-
SELIN_RS05050	1063948..1064244	+	297	WP_013505600.1	N(2)-fixation sustaining protein CowN	-
SELIN_RS05055	1064368..1065174	-	807	WP_013505601.1	class I SAM-dependent methyltransferase	-
SELIN_RS05060	1065394..1065693	-	300	WP_013505602.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SELIN_RS05065	1065683..1065928	-	246	WP_013505603.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SELIN_RS05070	1066108..1067289	+	1182	WP_013505604.1	NAD(P)/FAD-dependent oxidoreductase	-
SELIN_RS05075	1067642..1069198	-	1557	WP_013505605.1	glutamine-hydrolyzing GMP synthase	-
SELIN_RS05080	1069200..1070669	-	1470	WP_013505606.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-71)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11380.27 Da
• Isoelectric Point: 10.5021

>T25015 WP_013505602.1 NC_014836:c1065693-1065394 [Desulfurispirillum indicum S5]
MTYKLRFHEKALAEWRALDNSIREPLKRKLASRLQQPHVPADALSGMPNCYKIKLKRIGYRLVYQVCNDTVVVSVIAVGK
RDKNHVYGSANTRLETDKP

Nucleotide

• Length: 300 bp

>T25015 NC_014836:c1065693-1065394 [Desulfurispirillum indicum S5]
ATGACCTATAAGCTGCGCTTTCACGAAAAAGCCCTTGCCGAATGGCGCGCACTGGACAACAGTATTCGCGAACCCCTCAA
AAGAAAACTTGCCAGCCGACTGCAACAGCCCCATGTTCCTGCCGATGCCCTCAGCGGCATGCCCAACTGTTATAAAATCA
AACTCAAACGCATTGGATATCGCCTGGTATATCAGGTCTGCAACGACACCGTAGTGGTATCTGTGATCGCGGTAGGCAAG
CGCGACAAAAACCATGTTTATGGTAGCGCCAATACTCGGCTGGAAACGGACAAGCCGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9361.63 Da
• Isoelectric Point: 4.1528

>AT25015 WP_013505603.1 NC_014836:c1065928-1065683 [Desulfurispirillum indicum S5]
MESILADATVSVTELKRSYAEILRKAEDFPVAILNHNRPEAYLLPAAYYERLLERLEDIEDALLIRERQEGPFIEVSLDD
L

Nucleotide

• Length: 246 bp

>AT25015 NC_014836:c1065928-1065683 [Desulfurispirillum indicum S5]
ATGGAATCCATCCTGGCAGATGCAACGGTGAGCGTAACGGAACTCAAGCGCAGCTATGCTGAAATCCTGCGAAAGGCTGA
GGACTTCCCCGTAGCCATCCTGAATCATAATCGCCCGGAAGCCTACCTGCTGCCTGCGGCCTATTATGAACGGCTTTTGG
AGCGTCTGGAAGATATCGAAGATGCTTTACTGATACGAGAGCGACAAGAGGGGCCGTTTATTGAGGTAAGCCTCGATGAC
CTATAA

Structures

Toxin

• AlphaFold DB: E6W358

Antitoxin

• AlphaFold DB: E6W359