Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 257482..259070 Replicon chromosome
Accession NZ_CP100102
Organism Klebsiella pneumoniae strain HSKP33

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NIL14_RS01275 Protein ID WP_004179815.1
Coordinates 257482..258804 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NIL14_RS01280 Protein ID WP_004176198.1
Coordinates 258804..259070 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL14_RS01260 (252538) 252538..255039 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
NIL14_RS01265 (255027) 255027..256031 + 1005 WP_004179822.1 fimbrial protein -
NIL14_RS01270 (256173) 256173..257465 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NIL14_RS01275 (257482) 257482..258804 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
NIL14_RS01280 (258804) 258804..259070 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NIL14_RS01285 (259336) 259336..259662 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NIL14_RS01290 (259659) 259659..260159 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NIL14_RS01295 (260137) 260137..261516 - 1380 WP_094932908.1 nucleobase:cation symporter-2 family protein -
NIL14_RS01300 (261862) 261862..263016 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NIL14_RS01305 (262997) 262997..263920 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T250149 WP_004179815.1 NZ_CP100102:c258804-257482 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT250149 WP_004176198.1 NZ_CP100102:c259070-258804 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References