Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4855523..4856039 Replicon chromosome
Accession NZ_CP100094
Organism Klebsiella pneumoniae strain HSKP5

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NIL16_RS23525 Protein ID WP_004178374.1
Coordinates 4855523..4855807 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NIL16_RS23530 Protein ID WP_002886901.1
Coordinates 4855797..4856039 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL16_RS23500 (4851007) 4851007..4851270 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
NIL16_RS23505 (4851400) 4851400..4851573 + 174 WP_032408826.1 hypothetical protein -
NIL16_RS23510 (4851576) 4851576..4852319 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NIL16_RS23515 (4852676) 4852676..4854814 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NIL16_RS23520 (4855055) 4855055..4855519 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NIL16_RS23525 (4855523) 4855523..4855807 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL16_RS23530 (4855797) 4855797..4856039 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NIL16_RS23535 (4856117) 4856117..4858027 - 1911 WP_004178373.1 PRD domain-containing protein -
NIL16_RS23540 (4858050) 4858050..4859204 - 1155 WP_004178372.1 lactonase family protein -
NIL16_RS23545 (4859271) 4859271..4860011 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T250122 WP_004178374.1 NZ_CP100094:c4855807-4855523 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250122 WP_002886901.1 NZ_CP100094:c4856039-4855797 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References