Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2735666..2737254 Replicon chromosome
Accession NZ_CP100094
Organism Klebsiella pneumoniae strain HSKP5

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NIL16_RS13380 Protein ID WP_004179815.1
Coordinates 2735666..2736988 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NIL16_RS13385 Protein ID WP_004176198.1
Coordinates 2736988..2737254 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL16_RS13365 (2730722) 2730722..2733223 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
NIL16_RS13370 (2733211) 2733211..2734215 + 1005 WP_004179822.1 fimbrial protein -
NIL16_RS13375 (2734357) 2734357..2735649 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NIL16_RS13380 (2735666) 2735666..2736988 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
NIL16_RS13385 (2736988) 2736988..2737254 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NIL16_RS13390 (2737520) 2737520..2737846 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NIL16_RS13395 (2737843) 2737843..2738343 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NIL16_RS13400 (2738321) 2738321..2739700 - 1380 WP_094932908.1 nucleobase:cation symporter-2 family protein -
NIL16_RS13405 (2740046) 2740046..2741200 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NIL16_RS13410 (2741181) 2741181..2742104 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T250118 WP_004179815.1 NZ_CP100094:c2736988-2735666 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT250118 WP_004176198.1 NZ_CP100094:c2737254-2736988 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References