250110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2671..3251 Replicon plasmid pHSKP8-4
Accession NZ_CP100091
Organism Klebsiella pneumoniae strain HSKP8

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag NIL17_RS28330 Protein ID WP_071177730.1
Coordinates 2671..2985 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NIL17_RS28335 Protein ID WP_000093040.1
Coordinates 2973..3251 (-) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL17_RS28310 (NIL17_28290) 579..1310 + 732 WP_071177728.1 MobC family replication-relaxation protein -
NIL17_RS28315 (NIL17_28295) 1317..1847 + 531 WP_071177729.1 hypothetical protein -
NIL17_RS28320 (NIL17_28300) 1874..2053 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
NIL17_RS28325 (NIL17_28305) 2079..2507 - 429 WP_001140599.1 hypothetical protein -
NIL17_RS28330 (NIL17_28310) 2671..2985 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL17_RS28335 (NIL17_28315) 2973..3251 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NIL17_RS28340 (NIL17_28320) 3426..3791 - 366 WP_072354022.1 TonB family protein -
NIL17_RS28345 (NIL17_28325) 3788..4159 - 372 WP_001237044.1 cell envelope integrity protein TolA -
NIL17_RS28350 (NIL17_28330) 4433..4678 - 246 WP_032440458.1 hypothetical protein -
NIL17_RS28355 (NIL17_28335) 5005..6690 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
NIL17_RS28360 (NIL17_28340) 6700..6957 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -
NIL17_RS28365 (NIL17_28345) 7042..7191 + 150 WP_032440454.1 colicin release lysis protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T250110 WP_071177730.1 NZ_CP100091:c2985-2671 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp


Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT250110 WP_000093040.1 NZ_CP100091:c3251-2973 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References