Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1427311..1427968 Replicon chromosome
Accession NZ_CP100087
Organism Klebsiella pneumoniae strain HSKP8

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NIL17_RS06975 Protein ID WP_002916310.1
Coordinates 1427558..1427968 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NIL17_RS06970 Protein ID WP_002916312.1
Coordinates 1427311..1427577 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL17_RS06945 (1422467) 1422467..1423900 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
NIL17_RS06950 (1424019) 1424019..1424747 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NIL17_RS06955 (1424797) 1424797..1425108 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NIL17_RS06960 (1425272) 1425272..1425931 + 660 WP_002916317.1 hemolysin III family protein -
NIL17_RS06965 (1426082) 1426082..1427065 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
NIL17_RS06970 (1427311) 1427311..1427577 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NIL17_RS06975 (1427558) 1427558..1427968 + 411 WP_002916310.1 protein YgfX Toxin
NIL17_RS06980 (1427975) 1427975..1428496 - 522 WP_004144730.1 flavodoxin FldB -
NIL17_RS06985 (1428597) 1428597..1429493 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NIL17_RS06990 (1429516) 1429516..1430229 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIL17_RS06995 (1430235) 1430235..1431968 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250096 WP_002916310.1 NZ_CP100087:1427558-1427968 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250096 WP_002916312.1 NZ_CP100087:1427311-1427577 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References