Detailed information of TA system TA250092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 185355..187036
• Replicon: chromosome
• Accession: NZ_CP100087
• Organism: Klebsiella pneumoniae strain HSKP8

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: NIL17_RS00930
• Protein ID: WP_004178299.1
• Coordinates: 185355..186272 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: NIL17_RS00935
• Protein ID: WP_004177809.1
• Coordinates: 186278..187036 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIL17_RS00910 (180661)	180661..182181	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
NIL17_RS00915 (182178)	182178..183176	+	999	WP_002885172.1	ribose ABC transporter permease	-
NIL17_RS00920 (183207)	183207..184148	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
NIL17_RS00925 (184223)	184223..185230	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
NIL17_RS00930 (185355)	185355..186272	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NIL17_RS00935 (186278)	186278..187036	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NIL17_RS00940 (187122)	187122..187850	-	729	WP_004178298.1	response regulator transcription factor	-
NIL17_RS00945 (188123)	188123..190270	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
NIL17_RS00950 (190267)	190267..190410	-	144	WP_022631365.1	hypothetical protein	-
NIL17_RS00955 (190848)	190848..191534	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T250092 WP_004178299.1 NZ_CP100087:c186272-185355 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT250092 WP_004177809.1 NZ_CP100087:c187036-186278 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05