Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2776418..2778006 Replicon chromosome
Accession NZ_CP100084
Organism Klebsiella pneumoniae strain HSKP86

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NIL18_RS13570 Protein ID WP_004179815.1
Coordinates 2776418..2777740 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NIL18_RS13575 Protein ID WP_004176198.1
Coordinates 2777740..2778006 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL18_RS13555 (2771474) 2771474..2773975 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
NIL18_RS13560 (2773963) 2773963..2774967 + 1005 WP_004179822.1 fimbrial protein -
NIL18_RS13565 (2775109) 2775109..2776401 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NIL18_RS13570 (2776418) 2776418..2777740 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
NIL18_RS13575 (2777740) 2777740..2778006 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NIL18_RS13580 (2778272) 2778272..2778598 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NIL18_RS13585 (2778595) 2778595..2779095 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NIL18_RS13590 (2779073) 2779073..2780452 - 1380 WP_094932908.1 nucleobase:cation symporter-2 family protein -
NIL18_RS13595 (2780798) 2780798..2781952 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NIL18_RS13600 (2781933) 2781933..2782856 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T250079 WP_004179815.1 NZ_CP100084:c2777740-2776418 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT250079 WP_004176198.1 NZ_CP100084:c2778006-2777740 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References