Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 846597..847254 Replicon chromosome
Accession NZ_CP100084
Organism Klebsiella pneumoniae strain HSKP86

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NIL18_RS04225 Protein ID WP_002916310.1
Coordinates 846844..847254 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NIL18_RS04220 Protein ID WP_002916312.1
Coordinates 846597..846863 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL18_RS04195 (841753) 841753..843186 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
NIL18_RS04200 (843305) 843305..844033 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NIL18_RS04205 (844083) 844083..844394 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NIL18_RS04210 (844558) 844558..845217 + 660 WP_002916317.1 hemolysin III family protein -
NIL18_RS04215 (845368) 845368..846351 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
NIL18_RS04220 (846597) 846597..846863 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NIL18_RS04225 (846844) 846844..847254 + 411 WP_002916310.1 protein YgfX Toxin
NIL18_RS04230 (847261) 847261..847782 - 522 WP_004144730.1 flavodoxin FldB -
NIL18_RS04235 (847883) 847883..848779 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NIL18_RS04240 (848802) 848802..849515 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIL18_RS04245 (849521) 849521..851254 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250074 WP_002916310.1 NZ_CP100084:846844-847254 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250074 WP_002916312.1 NZ_CP100084:846597-846863 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References