Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5152017..5152642 Replicon chromosome
Accession NZ_CP100076
Organism Klebsiella pneumoniae strain RJKP36

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NIL00_RS24810 Protein ID WP_002882817.1
Coordinates 5152017..5152400 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NIL00_RS24815 Protein ID WP_004150355.1
Coordinates 5152400..5152642 (-) Length 81 a.a.

Genomic Context


NIL00_RS24795NIL00_RS24800NIL00_RS24805NIL00_RS24820NIL00_RS24810NIL00_RS24815NIL00_RS24825NIL00_RS24830NIL00_RS24835NIL00_RS24840
Location: 5149383..5150285 (903 bp)
Type: Others
Protein ID: WP_002882822.1
Location: 5150282..5150917 (636 bp)
Type: Others
Protein ID: WP_002882818.1
Location: 5150914..5151843 (930 bp)
Type: Others
Protein ID: WP_004150358.1
Location: 5152847..5153764 (918 bp)
Type: Others
Protein ID: WP_004181612.1
Location: 5152017..5152400 (384 bp)
Type: Toxin
Protein ID: WP_002882817.1
Location: 5152400..5152642 (243 bp)
Type: Antitoxin
Protein ID: WP_004150355.1
Location: 5153778..5154719 (942 bp)
Type: Others
Protein ID: WP_004178031.1
Location: 5154764..5155201 (438 bp)
Type: Others
Protein ID: WP_002882809.1
Location: 5155198..5156058 (861 bp)
Type: Others
Protein ID: WP_004146232.1
Location: 5156052..5156651 (600 bp)
Type: Others
Protein ID: WP_004151865.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NIL00_RS24795 (5149383)5149383..5150285+903WP_002882822.1formate dehydrogenase subunit beta-
NIL00_RS24800 (5150282)5150282..5150917+636WP_002882818.1formate dehydrogenase cytochrome b556 subunit-
NIL00_RS24805 (5150914)5150914..5151843+930WP_004150358.1formate dehydrogenase accessory protein FdhE-
NIL00_RS24810 (5152017)5152017..5152400-384WP_002882817.1type II toxin-antitoxin system VapC family toxinToxin
NIL00_RS24815 (5152400)5152400..5152642-243WP_004150355.1CopG family transcriptional regulatorAntitoxin
NIL00_RS24820 (5152847)5152847..5153764+918WP_004181612.1alpha/beta hydrolase-
NIL00_RS24825 (5153778)5153778..5154719-942WP_004178031.1fatty acid biosynthesis protein FabY-
NIL00_RS24830 (5154764)5154764..5155201-438WP_002882809.1D-aminoacyl-tRNA deacylase-
NIL00_RS24835 (5155198)5155198..5156058-861WP_004146232.1virulence factor BrkB family protein-
NIL00_RS24840 (5156052)5156052..5156651-600WP_004151865.1glucose-1-phosphatase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-112)

Antitoxin

(16-47)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T250067 WP_002882817.1 NZ_CP100076:c5152400-5152017 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT250067 WP_004150355.1 NZ_CP100076:c5152642-5152400 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GPK8


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GGU9

References