Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4683290..4683806 Replicon chromosome
Accession NZ_CP100076
Organism Klebsiella pneumoniae strain RJKP36

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NIL00_RS22580 Protein ID WP_004178374.1
Coordinates 4683290..4683574 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NIL00_RS22585 Protein ID WP_002886901.1
Coordinates 4683564..4683806 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL00_RS22555 (4678774) 4678774..4679082 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
NIL00_RS22560 (4679167) 4679167..4679340 + 174 WP_032408826.1 hypothetical protein -
NIL00_RS22565 (4679343) 4679343..4680086 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NIL00_RS22570 (4680443) 4680443..4682581 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NIL00_RS22575 (4682822) 4682822..4683286 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NIL00_RS22580 (4683290) 4683290..4683574 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL00_RS22585 (4683564) 4683564..4683806 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NIL00_RS22590 (4683884) 4683884..4685794 - 1911 WP_004178373.1 PRD domain-containing protein -
NIL00_RS22595 (4685817) 4685817..4686971 - 1155 WP_004178372.1 lactonase family protein -
NIL00_RS22600 (4687038) 4687038..4687778 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T250065 WP_004178374.1 NZ_CP100076:c4683574-4683290 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250065 WP_002886901.1 NZ_CP100076:c4683806-4683564 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References