Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2674818..2676406 Replicon chromosome
Accession NZ_CP100076
Organism Klebsiella pneumoniae strain RJKP36

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NIL00_RS12965 Protein ID WP_004179815.1
Coordinates 2674818..2676140 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NIL00_RS12970 Protein ID WP_004176198.1
Coordinates 2676140..2676406 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL00_RS12950 (2669874) 2669874..2672375 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
NIL00_RS12955 (2672363) 2672363..2673367 + 1005 WP_004179822.1 fimbrial protein -
NIL00_RS12960 (2673509) 2673509..2674801 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NIL00_RS12965 (2674818) 2674818..2676140 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
NIL00_RS12970 (2676140) 2676140..2676406 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NIL00_RS12975 (2676672) 2676672..2676998 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NIL00_RS12980 (2676995) 2676995..2677495 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NIL00_RS12985 (2677473) 2677473..2678852 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
NIL00_RS12990 (2679198) 2679198..2680352 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NIL00_RS12995 (2680333) 2680333..2681256 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T250062 WP_004179815.1 NZ_CP100076:c2676140-2674818 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT250062 WP_004176198.1 NZ_CP100076:c2676406-2676140 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References