Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 783531..784188 Replicon chromosome
Accession NZ_CP100076
Organism Klebsiella pneumoniae strain RJKP36

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NIL00_RS03845 Protein ID WP_002916310.1
Coordinates 783778..784188 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NIL00_RS03840 Protein ID WP_002916312.1
Coordinates 783531..783797 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL00_RS03815 (778687) 778687..780120 - 1434 WP_020324925.1 6-phospho-beta-glucosidase -
NIL00_RS03820 (780239) 780239..780967 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NIL00_RS03825 (781017) 781017..781328 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NIL00_RS03830 (781492) 781492..782151 + 660 WP_002916317.1 hemolysin III family protein -
NIL00_RS03835 (782302) 782302..783285 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
NIL00_RS03840 (783531) 783531..783797 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NIL00_RS03845 (783778) 783778..784188 + 411 WP_002916310.1 protein YgfX Toxin
NIL00_RS03850 (784195) 784195..784716 - 522 WP_004144730.1 flavodoxin FldB -
NIL00_RS03855 (784817) 784817..785713 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NIL00_RS03860 (785736) 785736..786449 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIL00_RS03865 (786455) 786455..788188 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250057 WP_002916310.1 NZ_CP100076:783778-784188 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250057 WP_002916312.1 NZ_CP100076:783531-783797 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References