250054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 547..1021 Replicon plasmid pRJKP41-3
Accession NZ_CP100075
Organism Klebsiella pneumoniae strain RJKP41

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag NIL01_RS27670 Protein ID WP_004197762.1
Coordinates 755..1021 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag NIL01_RS27665 Protein ID WP_000879771.1
Coordinates 547..771 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL01_RS27665 (NIL01_27655) 547..771 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
NIL01_RS27670 (NIL01_27660) 755..1021 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL01_RS27675 (NIL01_27665) 1091..1441 - 351 WP_004197756.1 hypothetical protein -
NIL01_RS27680 (NIL01_27670) 1507..2052 - 546 WP_023317533.1 hypothetical protein -
NIL01_RS27685 (NIL01_27675) 2078..2404 - 327 WP_050516389.1 hypothetical protein -
NIL01_RS27690 (NIL01_27680) 3560..3736 + 177 WP_004197757.1 hypothetical protein -
NIL01_RS27695 (NIL01_27685) 3726..4070 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
NIL01_RS27700 (NIL01_27690) 4279..4713 + 435 Protein_7 relaxase/mobilization nuclease domain-containing protein -
NIL01_RS27705 (NIL01_27695) 4748..5257 + 510 WP_032433972.1 MbeB family mobilization protein -
NIL01_RS27710 (NIL01_27700) 5264..5476 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T250054 WP_004197762.1 NZ_CP100075:755-1021 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT250054 WP_000879771.1 NZ_CP100075:547-771 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References