Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5316698..5317323 Replicon chromosome
Accession NZ_CP100072
Organism Klebsiella pneumoniae strain RJKP41

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NIL01_RS25710 Protein ID WP_002882817.1
Coordinates 5316698..5317081 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NIL01_RS25715 Protein ID WP_004150355.1
Coordinates 5317081..5317323 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL01_RS25695 (5314064) 5314064..5314966 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NIL01_RS25700 (5314963) 5314963..5315598 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NIL01_RS25705 (5315595) 5315595..5316524 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NIL01_RS25710 (5316698) 5316698..5317081 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NIL01_RS25715 (5317081) 5317081..5317323 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NIL01_RS25720 (5317528) 5317528..5318445 + 918 WP_004181612.1 alpha/beta hydrolase -
NIL01_RS25725 (5318459) 5318459..5319400 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NIL01_RS25730 (5319445) 5319445..5319882 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NIL01_RS25735 (5319879) 5319879..5320739 - 861 WP_004146232.1 virulence factor BrkB family protein -
NIL01_RS25740 (5320733) 5320733..5321332 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T250044 WP_002882817.1 NZ_CP100072:c5317081-5316698 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT250044 WP_004150355.1 NZ_CP100072:c5317323-5317081 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References