Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5003706..5005387 Replicon chromosome
Accession NZ_CP100072
Organism Klebsiella pneumoniae strain RJKP41

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag NIL01_RS24270 Protein ID WP_004178299.1
Coordinates 5003706..5004623 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NIL01_RS24275 Protein ID WP_004177809.1
Coordinates 5004629..5005387 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL01_RS24250 (4999012) 4999012..5000532 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NIL01_RS24255 (5000529) 5000529..5001527 + 999 WP_002885172.1 ribose ABC transporter permease -
NIL01_RS24260 (5001558) 5001558..5002499 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NIL01_RS24265 (5002574) 5002574..5003581 + 1008 WP_004178300.1 carbohydrate kinase family protein -
NIL01_RS24270 (5003706) 5003706..5004623 - 918 WP_004178299.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NIL01_RS24275 (5004629) 5004629..5005387 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NIL01_RS24280 (5005473) 5005473..5006201 - 729 WP_004178298.1 response regulator transcription factor -
NIL01_RS24285 (5006474) 5006474..5008621 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
NIL01_RS24290 (5008618) 5008618..5008761 - 144 WP_022631365.1 hypothetical protein -
NIL01_RS24295 (5009083) 5009083..5009769 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34649.06 Da        Isoelectric Point: 5.4707

>T250043 WP_004178299.1 NZ_CP100072:c5004623-5003706 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT250043 WP_004177809.1 NZ_CP100072:c5005387-5004629 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References