Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4848010..4848526 Replicon chromosome
Accession NZ_CP100072
Organism Klebsiella pneumoniae strain RJKP41

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NIL01_RS23480 Protein ID WP_004178374.1
Coordinates 4848010..4848294 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NIL01_RS23485 Protein ID WP_002886901.1
Coordinates 4848284..4848526 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL01_RS23455 (4843494) 4843494..4843757 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
NIL01_RS23460 (4843887) 4843887..4844060 + 174 WP_032408826.1 hypothetical protein -
NIL01_RS23465 (4844063) 4844063..4844806 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NIL01_RS23470 (4845163) 4845163..4847301 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NIL01_RS23475 (4847542) 4847542..4848006 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NIL01_RS23480 (4848010) 4848010..4848294 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL01_RS23485 (4848284) 4848284..4848526 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NIL01_RS23490 (4848604) 4848604..4850514 - 1911 WP_004178373.1 PRD domain-containing protein -
NIL01_RS23495 (4850537) 4850537..4851691 - 1155 WP_004178372.1 lactonase family protein -
NIL01_RS23500 (4851758) 4851758..4852498 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T250042 WP_004178374.1 NZ_CP100072:c4848294-4848010 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250042 WP_002886901.1 NZ_CP100072:c4848526-4848284 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References