Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 924769..925298 Replicon chromosome
Accession NZ_CP099990
Organism Staphylococcus equorum strain PU1

Toxin (Protein)


Gene name mazF Uniprot ID K7S376
Locus tag NHN23_RS04390 Protein ID WP_002511418.1
Coordinates 924936..925298 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID J9GY23
Locus tag NHN23_RS04385 Protein ID WP_002507108.1
Coordinates 924769..924939 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHN23_RS04360 920520..920999 + 480 WP_021339947.1 PH domain-containing protein -
NHN23_RS04365 920992..922497 + 1506 WP_021339948.1 PH domain-containing protein -
NHN23_RS04370 922490..923026 + 537 WP_002507105.1 PH domain-containing protein -
NHN23_RS04375 923059..923409 + 351 WP_021339949.1 holo-ACP synthase -
NHN23_RS04380 923533..924681 + 1149 WP_253345678.1 alanine racemase -
NHN23_RS04385 924769..924939 + 171 WP_002507108.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NHN23_RS04390 924936..925298 + 363 WP_002511418.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NHN23_RS04395 925657..926653 + 997 Protein_867 PP2C family protein-serine/threonine phosphatase -
NHN23_RS04400 926733..927059 + 327 WP_002511417.1 anti-sigma factor antagonist -
NHN23_RS04405 927061..927543 + 483 WP_002507113.1 anti-sigma B factor RsbW -
NHN23_RS04410 927518..928288 + 771 WP_002507114.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13432.59 Da        Isoelectric Point: 10.2178

>T250028 WP_002511418.1 NZ_CP099990:924936-925298 [Staphylococcus equorum]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSESKMKEVNVAIDISLGLHNVRNSKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6305.92 Da        Isoelectric Point: 4.0121

>AT250028 WP_002507108.1 NZ_CP099990:924769-924939 [Staphylococcus equorum]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYLSSKNNNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7S376

Antitoxin

Source ID Structure
AlphaFold DB J9GY23

References