Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 913319..913839 Replicon chromosome
Accession NZ_CP099990
Organism Staphylococcus equorum strain PU1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A192F7F2
Locus tag NHN23_RS04330 Protein ID WP_031266142.1
Coordinates 913627..913839 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID J9GWP4
Locus tag NHN23_RS04325 Protein ID WP_002507096.1
Coordinates 913319..913612 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHN23_RS04300 908456..909247 + 792 WP_253345726.1 hydroxyethylthiazole kinase -
NHN23_RS04305 909247..909885 + 639 WP_021339941.1 thiamine phosphate synthase -
NHN23_RS04310 909973..910842 + 870 WP_002507093.1 membrane protein insertase YidC -
NHN23_RS04315 910913..911563 - 651 WP_021339942.1 HD domain-containing protein -
NHN23_RS04320 911691..913175 - 1485 WP_253345676.1 cardiolipin synthase -
NHN23_RS04325 913319..913612 + 294 WP_002507096.1 copper-sensing transcriptional repressor CsoR Antitoxin
NHN23_RS04330 913627..913839 + 213 WP_031266142.1 heavy metal-associated domain-containing protein Toxin
NHN23_RS04335 914034..914174 + 141 WP_002507098.1 Lmo0850 family protein -
NHN23_RS04340 914330..915532 - 1203 WP_002507099.1 rod shape-determining protein RodA -
NHN23_RS04345 915807..916877 + 1071 WP_002507100.1 D-alanine--D-alanine ligase -
NHN23_RS04350 916890..918245 + 1356 WP_021339945.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(18-67)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8116.13 Da        Isoelectric Point: 4.5086

>T250027 WP_031266142.1 NZ_CP099990:913627-913839 [Staphylococcus equorum]
VVTKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Download         Length: 213 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.87 Da        Isoelectric Point: 6.4791

>AT250027 WP_002507096.1 NZ_CP099990:913319-913612 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192F7F2

Antitoxin

Source ID Structure
AlphaFold DB J9GWP4

References