250022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 4324..4798 Replicon plasmid unnamed1
Accession NZ_CP099976
Organism Halomonas sp. Y3

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag NHL60_RS19415 Protein ID WP_253452434.1
Coordinates 4532..4798 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag NHL60_RS19410 Protein ID WP_095623473.1
Coordinates 4324..4548 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHL60_RS19385 71..1615 + 1545 WP_008175578.1 IS66 family transposase -
NHL60_RS19390 1866..2429 - 564 WP_001097412.1 chlorite dismutase family protein -
NHL60_RS19395 2453..2827 - 375 WP_001348195.1 cupin domain-containing protein -
NHL60_RS19400 3017..3453 - 437 Protein_3 IS66 family transposase -
NHL60_RS19405 3579..3803 + 225 WP_253452431.1 hypothetical protein -
NHL60_RS19410 4324..4548 + 225 WP_095623473.1 DUF6290 family protein Antitoxin
NHL60_RS19415 4532..4798 + 267 WP_253452434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHL60_RS19420 4828..5718 - 891 WP_253452437.1 replication initiation protein -
NHL60_RS19425 6201..7124 - 924 WP_253452440.1 DNA-binding protein -
NHL60_RS19430 7322..7483 - 162 WP_253452443.1 hypothetical protein -
NHL60_RS19435 7820..8737 + 918 WP_253452446.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..24166 24166
- flank IS/Tn - - 71..1615 1544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(3-70)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10424.12 Da        Isoelectric Point: 10.6896

>T250022 WP_253452434.1 NZ_CP099976:4532-4798 [Halomonas sp. Y3]
MAWRIELTDEAVKQLKKIGHADAKRIRDYLRGRLQPLEDPRQLGKPLTGQLSELWRYRVGNYRLIASIEDDEIRVLVVRI
GHRSKVYR

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8516.60 Da        Isoelectric Point: 4.3529

>AT250022 WP_095623473.1 NZ_CP099976:4324-4548 [Halomonas sp. Y3]
MLALRLPTEIEERLEALAKATGRTKSYYAREAILEHLDDLEDIYLAEKTLEQVRRGEMTTHSLDDVERELGLAD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References