Detailed information of TA system TA250020

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/COG3657-dnstrm_HI1420
• Location: 2326816..2327430
• Replicon: chromosome
• Accession: NZ_CP099975
• Organism: Halomonas sp. Y3

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: NHL60_RS11125
• Protein ID: WP_253443270.1
• Coordinates: 2326816..2327112 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: NHL60_RS11130
• Protein ID: WP_253443271.1
• Coordinates: 2327116..2327430 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
-	2327116..2327430	+	315	-	-	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2319954..2332505	12551

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-96)

Antitoxin

• Cro/C1-type helix-turn-helix domain (50-93)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11026.86 Da
• Isoelectric Point: 10.5786

>T250020 WP_253443270.1 NZ_CP099975:2326816-2327112 [Halomonas sp. Y3]
MIELIKTDVFDRWLRSLRDTRARAKITVRLRRLSLGNPGDVKPVGEGISELRIPHGPGYRVYYLTRGPIVVVLLCGGDKG
SQPSDIEQAKAIAKQWKE

Nucleotide

• Length: 297 bp

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11170.62 Da
• Isoelectric Point: 4.2837

>AT250020 WP_253443271.1 NZ_CP099975:2327116-2327430 [Halomonas sp. Y3]
MATQQQVTFSHYDTAEYLQTEEEIAAYLEAVMEENDPSLLAAALGDVARARNMSQLAKEVGMSREGLYKALSGEGNPAFS
TINKVANALGLQLTIKPMSPPPAP

Nucleotide

• Length: 315 bp