Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1985534..1986139 Replicon chromosome
Accession NZ_CP099975
Organism Halomonas sp. Y3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NHL60_RS09435 Protein ID WP_253451726.1
Coordinates 1985534..1985716 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NHL60_RS09440 Protein ID WP_253451728.1
Coordinates 1985735..1986139 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHL60_RS09415 1980883..1981923 + 1041 WP_253451716.1 protease SohB -
NHL60_RS09420 1981920..1982243 - 324 WP_253451718.1 metalloregulator ArsR/SmtB family transcription factor -
NHL60_RS09425 1982558..1984468 + 1911 WP_253451720.1 propionyl-CoA synthetase -
NHL60_RS09430 1984706..1985395 + 690 WP_253451723.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
NHL60_RS09435 1985534..1985716 + 183 WP_253451726.1 type II toxin-antitoxin system HicA family toxin Toxin
NHL60_RS09440 1985735..1986139 + 405 WP_253451728.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NHL60_RS09445 1986252..1987031 + 780 WP_253451731.1 alpha/beta fold hydrolase -
NHL60_RS09450 1987032..1988432 - 1401 WP_253451734.1 3'-5' exonuclease family protein -
NHL60_RS09455 1988432..1989607 - 1176 WP_253451738.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6679.75 Da        Isoelectric Point: 11.0468

>T250019 WP_253451726.1 NZ_CP099975:1985534-1985716 [Halomonas sp. Y3]
VKSSELIKELEAAGWVLDRIRGSHHVFKHPERSGAIPVPHPKKDLPRGTVHQIRKQAGLA

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14686.55 Da        Isoelectric Point: 4.3945

>AT250019 WP_253451728.1 NZ_CP099975:1985735-1986139 [Halomonas sp. Y3]
MQYPIAIEWGDDNTATGIVFPDIPGAISAGDSPEEAYDNAVEAAQIVLQELVSRGESVPKPGKINEHRRNPDFEGWGWGM
IDIDLTPYLGKTEKVTVTLPGIVVRQIDEYVTLHGIKSRSAFLSNAALEKLQHV

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References