Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179517..4180298 Replicon chromosome
Accession NZ_CP099973
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE006

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag NHL55_RS20455 Protein ID WP_000626100.1
Coordinates 4179517..4180008 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NHL55_RS20460 Protein ID WP_001110452.1
Coordinates 4180005..4180298 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHL55_RS20420 (4174977) 4174977..4175324 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
NHL55_RS20425 (4175300) 4175300..4177003 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
NHL55_RS20430 (4177040) 4177040..4177615 + 576 WP_001188509.1 transcriptional regulator -
NHL55_RS20440 (4177886) 4177886..4177960 - 75 Protein_3994 helix-turn-helix domain-containing protein -
NHL55_RS20445 (4178340) 4178340..4178417 + 78 Protein_3995 porin family protein -
NHL55_RS20450 (4178517) 4178517..4179269 + 753 WP_000842433.1 non-specific acid phosphatase -
NHL55_RS20455 (4179517) 4179517..4180008 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
NHL55_RS20460 (4180005) 4180005..4180298 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NHL55_RS20465 (4180615) 4180615..4180836 + 222 WP_001576552.1 hypothetical protein -
NHL55_RS20470 (4181102) 4181102..4181977 + 876 WP_000921676.1 AraC family transcriptional regulator -
NHL55_RS20475 (4181974) 4181974..4182261 + 288 WP_001541332.1 transcriptional regulator RtsB -
NHL55_RS20480 (4182254) 4182254..4182436 - 183 WP_001676222.1 ATP-binding cassette domain-containing protein -
NHL55_RS20485 (4182561) 4182561..4182809 + 249 Protein_4003 Ig-like domain-containing protein -
NHL55_RS20490 (4182921) 4182921..4183052 + 132 Protein_4004 hypothetical protein -
NHL55_RS20495 (4183346) 4183346..4184251 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T250013 WP_000626100.1 NZ_CP099973:c4180008-4179517 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT250013 WP_001110452.1 NZ_CP099973:c4180298-4180005 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References