Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4031496..4032046 Replicon chromosome
Accession NZ_CP099973
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE006

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag NHL55_RS19670 Protein ID WP_001199743.1
Coordinates 4031496..4031804 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag NHL55_RS19675 Protein ID WP_001118105.1
Coordinates 4031807..4032046 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHL55_RS19650 (4028070) 4028070..4028810 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
NHL55_RS19655 (4028932) 4028932..4029462 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
NHL55_RS19660 (4029785) 4029785..4030918 + 1134 Protein_3843 IS3 family transposase -
NHL55_RS19665 (4030950) 4030950..4031090 - 141 Protein_3844 Arm DNA-binding domain-containing protein -
NHL55_RS19670 (4031496) 4031496..4031804 - 309 WP_001199743.1 CcdB family protein Toxin
NHL55_RS19675 (4031807) 4031807..4032046 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NHL55_RS19680 (4032155) 4032155..4032403 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
NHL55_RS19685 (4032594) 4032594..4033025 - 432 Protein_3848 helix-turn-helix domain-containing protein -
NHL55_RS19695 (4033782) 4033782..4034801 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
NHL55_RS19700 (4034829) 4034829..4035359 - 531 WP_000896758.1 gluconokinase -
NHL55_RS19705 (4035576) 4035576..4036607 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029877..4032980 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T250011 WP_001199743.1 NZ_CP099973:c4031804-4031496 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT250011 WP_001118105.1 NZ_CP099973:c4032046-4031807 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References