Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411707..3412327 Replicon chromosome
Accession NZ_CP099973
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE006

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NHL55_RS16810 Protein ID WP_001280991.1
Coordinates 3412109..3412327 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NHL55_RS16805 Protein ID WP_000344807.1
Coordinates 3411707..3412081 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHL55_RS16795 (3406846) 3406846..3408039 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NHL55_RS16800 (3408062) 3408062..3411211 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NHL55_RS16805 (3411707) 3411707..3412081 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NHL55_RS16810 (3412109) 3412109..3412327 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NHL55_RS16815 (3412506) 3412506..3413057 + 552 WP_001278793.1 maltose O-acetyltransferase -
NHL55_RS16820 (3413175) 3413175..3413645 + 471 WP_000136183.1 YlaC family protein -
NHL55_RS16825 (3413701) 3413701..3413841 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NHL55_RS16830 (3413847) 3413847..3414107 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NHL55_RS16835 (3414332) 3414332..3415882 + 1551 WP_000213140.1 EAL domain-containing protein -
NHL55_RS16845 (3416113) 3416113..3416502 + 390 WP_000961287.1 MGMT family protein -
NHL55_RS16850 (3416535) 3416535..3417104 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T250007 WP_001280991.1 NZ_CP099973:3412109-3412327 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT250007 WP_000344807.1 NZ_CP099973:3411707-3412081 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References