Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3731252..3731877 Replicon chromosome
Accession NC_014815
Organism Micromonospora sp. L5

Toxin (Protein)


Gene name vapC Uniprot ID A0A1C6TLL3
Locus tag ML5_RS17685 Protein ID WP_013475595.1
Coordinates 3731252..3731671 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3M9KLX8
Locus tag ML5_RS17690 Protein ID WP_013475596.1
Coordinates 3731668..3731877 (-) Length 70 a.a.

Genomic Context

ML5_RS17655ML5_RS17660ML5_RS17675ML5_RS17680ML5_RS17700ML5_RS17650ML5_RS17665ML5_RS17670ML5_RS17685ML5_RS17690ML5_RS17695ML5_RS17705ML5_RS17710
Location: 3728463..3728732 (270 bp)
Type: Others
Protein ID: WP_174361730.1
Location: 3728729..3729010 (282 bp)
Type: Others
Protein ID: WP_083395318.1
Location: 3730504..3730818 (315 bp)
Type: Others
Protein ID: WP_013475594.1
Location: 3730815..3731069 (255 bp)
Type: Others
Protein ID: WP_013287870.1
Location: 3732957..3733700 (744 bp)
Type: Others
Protein ID: WP_013287866.1
Location: 3727229..3728368 (1140 bp)
Type: Others
Protein ID: WP_013475593.1
Location: 3729066..3729266 (201 bp)
Type: Others
Protein ID: WP_013287873.1
Location: 3729259..3730137 (879 bp)
Type: Others
Protein ID: WP_174361729.1
Location: 3731252..3731671 (420 bp)
Type: Toxin
Protein ID: WP_013475595.1
Location: 3731668..3731877 (210 bp)
Type: Antitoxin
Protein ID: WP_013475596.1
Location: 3731966..3732817 (852 bp)
Type: Others
Protein ID: WP_013475597.1
Location: 3733741..3734631 (891 bp)
Type: Others
Protein ID: WP_013475598.1
Location: 3734705..3736150 (1446 bp)
Type: Others
Protein ID: WP_013475599.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ML5_RS176503727229..3728368-1140WP_013475593.1site-2 protease family protein-
ML5_RS176553728463..3728732+270WP_174361730.1type II toxin-antitoxin system prevent-host-death family antitoxin-
ML5_RS176603728729..3729010+282WP_083395318.1type II toxin-antitoxin system RelE/ParE family toxin-
ML5_RS176653729066..3729266-201WP_013287873.1DUF397 domain-containing protein-
ML5_RS176703729259..3730137-879WP_174361729.1helix-turn-helix domain-containing protein-
ML5_RS176753730504..3730818+315WP_013475594.1DivIVA domain-containing protein-
ML5_RS176803730815..3731069+255WP_013287870.1hypothetical protein-
ML5_RS176853731252..3731671-420WP_013475595.1PIN domain nucleaseToxin
ML5_RS176903731668..3731877-210WP_013475596.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
ML5_RS176953731966..3732817-852WP_013475597.1alpha/beta fold hydrolase-
ML5_RS177003732957..3733700+744WP_013287866.13-oxoacyl-ACP reductase FabG-
ML5_RS177053733741..3734631-891WP_013475598.1L,D-transpeptidase-
ML5_RS177103734705..3736150-1446WP_013475599.1alpha-amylase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-119)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15376.68 Da        Isoelectric Point: 6.6416

>T25000 WP_013475595.1 NC_014815:c3731671-3731252 [Micromonospora sp. L5]
MTRERYLLDKSALARWPKPAVAPVLDELSDRGLLAVCGAIEIEVVHSARSAKDAKRARWLLRGFDWLAMPDDIWDRAIDI
QVQALHKGNHRALSMADLLIAATAERHGVTVLHYDGDFDLITAITGQPTTWVVPAGKAD

Download         Length: 420 bp

>T25000 NC_014815:c3731671-3731252 [Micromonospora sp. L5]
ATGACGCGGGAGCGCTACCTCCTCGACAAGTCGGCGCTGGCCCGGTGGCCGAAGCCCGCCGTGGCGCCGGTCCTGGACGA
GTTGTCCGATCGCGGTCTGCTGGCGGTCTGCGGCGCCATCGAGATCGAGGTCGTACACAGCGCCCGCTCGGCCAAGGACG
CGAAGCGCGCTCGATGGCTGCTCCGCGGTTTCGACTGGCTCGCCATGCCCGACGACATCTGGGATCGTGCGATCGACATC
CAGGTGCAGGCGCTGCACAAGGGCAACCACCGCGCGCTCTCGATGGCCGATCTGCTGATCGCCGCGACGGCCGAACGGCA
TGGCGTGACCGTTCTGCACTACGACGGTGACTTCGACCTGATCACCGCGATCACCGGCCAGCCGACGACGTGGGTCGTCC
CGGCCGGGAAGGCCGACTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7395.28 Da        Isoelectric Point: 4.3719

>AT25000 WP_013475596.1 NC_014815:c3731877-3731668 [Micromonospora sp. L5]
MSRTILDVDDDLLAEAAEILGTGTKKATVNAALQEVVNREKRREFADWLKSGGLPDLTDPGQASKPEAA

Download         Length: 210 bp

>AT25000 NC_014815:c3731877-3731668 [Micromonospora sp. L5]
ATGTCCCGCACCATTCTCGATGTCGACGACGACCTCCTGGCCGAGGCCGCCGAGATCCTCGGCACGGGCACCAAGAAGGC
CACTGTCAACGCCGCGCTGCAGGAAGTGGTCAACCGGGAGAAGCGCCGGGAGTTCGCCGACTGGCTCAAGAGCGGCGGCC
TGCCGGACCTCACCGACCCGGGGCAGGCGTCGAAGCCCGAAGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1C6TLL3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3M9KLX8

References