Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825025..825685 Replicon chromosome
Accession NZ_CP099973
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE006

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NHL55_RS03970 Protein ID WP_000244756.1
Coordinates 825272..825685 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NHL55_RS03965 Protein ID WP_000351186.1
Coordinates 825025..825291 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHL55_RS03945 (820954) 820954..822387 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
NHL55_RS03950 (822545) 822545..822856 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NHL55_RS03955 (823020) 823020..823679 + 660 WP_000250289.1 hemolysin III family protein -
NHL55_RS03960 (823795) 823795..824775 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
NHL55_RS03965 (825025) 825025..825291 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NHL55_RS03970 (825272) 825272..825685 + 414 WP_000244756.1 protein YgfX Toxin
NHL55_RS03975 (825738) 825738..826259 - 522 WP_001055885.1 flavodoxin FldB -
NHL55_RS03980 (826372) 826372..827268 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NHL55_RS03985 (827292) 827292..828005 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NHL55_RS03990 (828011) 828011..829744 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T249999 WP_000244756.1 NZ_CP099973:825272-825685 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT249999 WP_000351186.1 NZ_CP099973:825025-825291 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References