Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 310306..310892 Replicon chromosome
Accession NZ_CP099973
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE006

Toxin (Protein)


Gene name doc Uniprot ID A0A3V9X0E4
Locus tag NHL55_RS01415 Protein ID WP_000174964.1
Coordinates 310524..310892 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V7IU48
Locus tag NHL55_RS01410 Protein ID WP_001522145.1
Coordinates 310306..310527 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHL55_RS01385 (305327) 305327..306436 + 1110 WP_000822978.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NHL55_RS01390 (306496) 306496..307422 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NHL55_RS01395 (307419) 307419..308696 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
NHL55_RS01400 (308693) 308693..309460 + 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NHL55_RS01405 (309462) 309462..310175 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
NHL55_RS01410 (310306) 310306..310527 + 222 WP_001522145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NHL55_RS01415 (310524) 310524..310892 + 369 WP_000174964.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NHL55_RS01420 (311151) 311151..312467 + 1317 WP_000624755.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
NHL55_RS01425 (312572) 312572..313459 + 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
NHL55_RS01430 (313456) 313456..314301 + 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
NHL55_RS01435 (314303) 314303..315373 + 1071 WP_000907840.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 307419..316110 8691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13601.91 Da        Isoelectric Point: 6.7252

>T249997 WP_000174964.1 NZ_CP099973:310524-310892 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8166.17 Da        Isoelectric Point: 5.0775

>AT249997 WP_001522145.1 NZ_CP099973:310306-310527 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9X0E4

Antitoxin

Source ID Structure

References