Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1235742..1236339 Replicon chromosome
Accession NZ_CP099968
Organism Brucella pseudintermedia strain ASAG-D25

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag NIK97_RS17885 Protein ID WP_119039412.1
Coordinates 1236034..1236339 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag NIK97_RS17880 Protein ID WP_119039410.1
Coordinates 1235742..1236047 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIK97_RS17845 (NIK97_17810) 1231615..1232760 + 1146 WP_235925445.1 MFS transporter -
NIK97_RS17850 (NIK97_17815) 1232762..1233847 + 1086 WP_119039402.1 transporter substrate-binding domain-containing protein -
NIK97_RS17855 (NIK97_17820) 1233909..1234313 - 405 WP_119039404.1 type II toxin-antitoxin system VapC family toxin -
NIK97_RS17860 (NIK97_17825) 1234319..1234561 - 243 WP_119039406.1 type II toxin-antitoxin system VapB family antitoxin -
NIK97_RS17865 (NIK97_17830) 1234763..1234939 - 177 WP_162995063.1 hypothetical protein -
NIK97_RS17870 (NIK97_17835) 1234923..1235318 - 396 WP_119040851.1 hypothetical protein -
NIK97_RS17875 (NIK97_17840) 1235345..1235668 - 324 WP_119039408.1 helix-turn-helix transcriptional regulator -
NIK97_RS17880 (NIK97_17845) 1235742..1236047 - 306 WP_119039410.1 putative addiction module antidote protein Antitoxin
NIK97_RS17885 (NIK97_17850) 1236034..1236339 - 306 WP_119039412.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIK97_RS17890 (NIK97_17855) 1236445..1238364 - 1920 WP_119039414.1 ParB/RepB/Spo0J family partition protein -
NIK97_RS17895 (NIK97_17860) 1238765..1239187 + 423 WP_119039416.1 hypothetical protein -
NIK97_RS17900 (NIK97_17865) 1239289..1239576 - 288 WP_119039418.1 hypothetical protein -
NIK97_RS17905 (NIK97_17870) 1239872..1240144 + 273 WP_119039420.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - htpB 1105459..1331078 225619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-91)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.50 Da        Isoelectric Point: 9.3910

>T249995 WP_119039412.1 NZ_CP099968:c1236339-1236034 [Brucella pseudintermedia]
MLTIKRTTIFIDWLKGLKDRRAVARIAMRIDRFESGNPGHVRDVGDGVGEMKIDYGPGYRVYYVRREKTIYLLLCGGDKR
TQDRDIAEAKRIAKEWTDEED

Download         Length: 306 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10973.69 Da        Isoelectric Point: 5.1667

>AT249995 WP_119039410.1 NZ_CP099968:c1236047-1235742 [Brucella pseudintermedia]
MKKIEVAAWDSAEVLDTPEAIEEYLAAAFETEDPVFIAKALGVVARARNMSKLARNTGMTRAALYRAFNGETSPEFATIM
KIMHALGVSITPVVKKTEEAA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References