Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1289639..1290288 Replicon chromosome
Accession NZ_CP099967
Organism Brucella pseudintermedia strain ASAG-D25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NIK97_RS06250 Protein ID WP_144897092.1
Coordinates 1289639..1290037 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NIK97_RS06255 Protein ID WP_121981713.1
Coordinates 1290037..1290288 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIK97_RS06225 (NIK97_06210) 1284942..1285718 + 777 WP_176022914.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
NIK97_RS06230 (NIK97_06215) 1285895..1286866 - 972 WP_121985861.1 2-hydroxyacid dehydrogenase -
NIK97_RS06235 (NIK97_06220) 1286957..1287976 - 1020 WP_006471199.1 LacI family DNA-binding transcriptional regulator -
NIK97_RS06240 (NIK97_06225) 1288186..1288677 - 492 WP_121985860.1 MarR family transcriptional regulator -
NIK97_RS06245 (NIK97_06230) 1288847..1289629 + 783 WP_121985859.1 creatininase family protein -
NIK97_RS06250 (NIK97_06235) 1289639..1290037 - 399 WP_144897092.1 type II toxin-antitoxin system VapC family toxin Toxin
NIK97_RS06255 (NIK97_06240) 1290037..1290288 - 252 WP_121981713.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NIK97_RS06260 (NIK97_06245) 1290523..1291695 + 1173 WP_174813501.1 GTP-binding protein -
NIK97_RS06265 (NIK97_06250) 1291781..1292755 + 975 WP_121981711.1 WD40 repeat domain-containing protein -
NIK97_RS06270 (NIK97_06255) 1292900..1293778 - 879 WP_121985856.1 alpha/beta hydrolase -
NIK97_RS06275 (NIK97_06260) 1294123..1295082 + 960 WP_121985855.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-115)

Antitoxin

SpoVT-AbrB domain

(15-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 13966.20 Da        Isoelectric Point: 7.1658

>T249994 WP_144897092.1 NZ_CP099967:c1290037-1289639 [Brucella pseudintermedia]
MRYMLDTNIISDLVKNPAGSVAGHIRRVGADAVCTSIIVAAELRYGVLKKGSPALAERVEAILREIPVLPFDVPADAKYG
ALRAALEAKGQPIGGNNLLIAAHAATLGKTMVTANVSEFGRVSELSVENWLE

Download         Length: 399 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9584.08 Da        Isoelectric Point: 10.2811

>AT249994 WP_121981713.1 NZ_CP099967:c1290288-1290037 [Brucella pseudintermedia]
MSQKPRPKSREVRLFRNNRNQAIRIPVEFELPGDRALITRDGDRLIVEPLRRGGLLALLDSWKPLDEALPDVADRPVEPK
DIF

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References