Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2316710..2317314 Replicon chromosome
Accession NZ_CP099914
Organism Escherichia albertii strain 104_2_TS_A

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag NIY84_RS11225 Protein ID WP_000638401.1
Coordinates 2316928..2317314 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag NIY84_RS11220 Protein ID WP_001195490.1
Coordinates 2316710..2316931 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY84_RS11205 (2312960) 2312960..2314411 + 1452 WP_256878981.1 tagaturonate reductase -
NIY84_RS11210 (2314616) 2314616..2315530 + 915 WP_024164792.1 bestrophin family protein -
NIY84_RS11215 (2315534) 2315534..2316292 - 759 WP_025239009.1 trans-aconitate 2-methyltransferase -
NIY84_RS11220 (2316710) 2316710..2316931 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NIY84_RS11225 (2316928) 2316928..2317314 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T249981 WP_000638401.1 NZ_CP099914:2316928-2317314 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT249981 WP_001195490.1 NZ_CP099914:2316710-2316931 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References