Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4405815..4406850 Replicon chromosome
Accession NZ_CP099912
Organism Escherichia albertii strain 105_1_LWG_A

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NIY85_RS21895 Protein ID WP_256876785.1
Coordinates 4405815..4406354 (-) Length 180 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag NIY85_RS21900 Protein ID WP_000287252.1
Coordinates 4406377..4406850 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY85_RS21850 (4401188) 4401188..4401670 + 483 WP_059216138.1 siphovirus Gp157 family protein -
NIY85_RS21855 (4401682) 4401682..4401996 + 315 WP_059216137.1 hypothetical protein -
NIY85_RS21860 (4402013) 4402013..4402177 + 165 Protein_4281 DUF2737 family protein -
NIY85_RS21865 (4402174) 4402174..4402734 + 561 WP_059238939.1 hypothetical protein -
NIY85_RS21870 (4402951) 4402951..4403610 + 660 WP_059238951.1 ead/Ea22-like family protein -
NIY85_RS21875 (4403612) 4403612..4403790 + 179 Protein_4284 hypothetical protein -
NIY85_RS21880 (4404124) 4404124..4404903 + 780 WP_256876784.1 DUF551 domain-containing protein -
NIY85_RS21885 (4404903) 4404903..4405475 + 573 WP_001061339.1 3'-5' exonuclease -
NIY85_RS21890 (4405512) 4405512..4405781 + 270 WP_001093912.1 pyocin activator PrtN family protein -
NIY85_RS21895 (4405815) 4405815..4406354 - 540 WP_256876785.1 hypothetical protein Toxin
NIY85_RS21900 (4406377) 4406377..4406850 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
NIY85_RS21905 (4407373) 4407373..4407888 + 516 WP_002460756.1 zinc uptake transcriptional repressor Zur -
NIY85_RS21910 (4407929) 4407929..4408138 - 210 WP_001030604.1 CsbD family protein -
NIY85_RS21915 (4408254) 4408254..4409579 - 1326 WP_025237884.1 MATE family efflux transporter DinF -
NIY85_RS21920 (4409654) 4409654..4410262 - 609 WP_256876786.1 transcriptional repressor LexA -
NIY85_RS21925 (4410372) 4410372..4410740 - 369 WP_000002912.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4380713..4418825 38112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 180 a.a.        Molecular weight: 19749.07 Da        Isoelectric Point: 4.4481

>T249964 WP_256876785.1 NZ_CP099912:c4406354-4405815 [Escherichia albertii]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVVSGLFKSRKDSDKEK

Download         Length: 540 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT249964 WP_000287252.1 NZ_CP099912:c4406850-4406377 [Escherichia albertii]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References