Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-AbrB
Location 4804071..4804727 Replicon chromosome
Accession NC_014814
Organism Mycobacterium gilvum Spyr1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MSPYR1_RS27910 Protein ID WP_013472821.1
Coordinates 4804071..4804481 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MSPYR1_RS27915 Protein ID WP_013472822.1
Coordinates 4804488..4804727 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSPYR1_RS22715 4799319..4800107 + 789 WP_011896016.1 putative hydro-lyase -
MSPYR1_RS22720 4800191..4801273 - 1083 WP_013472819.1 acyl-CoA desaturase -
MSPYR1_RS22725 4801497..4804022 + 2526 WP_013472820.1 SEC-C domain-containing protein -
MSPYR1_RS27910 4804071..4804481 - 411 WP_013472821.1 PIN domain-containing protein Toxin
MSPYR1_RS27915 4804488..4804727 - 240 WP_013472822.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MSPYR1_RS22740 4804833..4805966 - 1134 WP_013472823.1 hypothetical protein -
MSPYR1_RS22745 4806087..4806476 + 390 WP_011896019.1 ParD-like family protein -
MSPYR1_RS22750 4806511..4807092 + 582 WP_013472824.1 zeta toxin family protein -
MSPYR1_RS22755 4807170..4808585 + 1416 WP_158022643.1 plasmid pRiA4b ORF-3 family protein -
MSPYR1_RS22760 4808684..4809085 - 402 WP_013472826.1 type II toxin-antitoxin system VapC family toxin -
MSPYR1_RS22765 4809072..4809302 - 231 WP_013472827.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

SpoVT-AbrB domain

(9-38)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14205.27 Da        Isoelectric Point: 10.0832

>T24996 WP_013472821.1 NC_014814:c4804481-4804071 [Mycolicibacterium gilvum Spyr1]
MLVTAVDTSVAVPLLVGSHREHAAVAKWAKGKTLGLSGHALTETYSVLTRLPGDARLLPQDAVALIDANFTASLTLGARV
ARRAHRELARRGIGGGATYDGLVALAAREHGVVLATRDARARATYEALSVDTEVVA

Download         Length: 411 bp

>T24996 NC_014814:c4804481-4804071 [Mycolicibacterium gilvum Spyr1]
ATGCTTGTCACAGCGGTCGATACAAGTGTCGCTGTACCGCTGCTCGTCGGCTCCCACCGAGAACACGCCGCCGTGGCGAA
ATGGGCCAAAGGCAAGACACTGGGACTCAGCGGGCATGCGCTGACCGAGACGTACTCGGTGCTGACACGGCTACCCGGTG
ATGCGCGGCTGCTCCCGCAGGATGCGGTCGCACTGATCGACGCCAACTTCACTGCATCCCTCACGCTCGGCGCCCGCGTC
GCACGTCGTGCGCATCGCGAGTTGGCTCGACGAGGGATCGGCGGCGGTGCGACTTATGACGGACTCGTTGCGCTGGCGGC
GCGAGAACACGGTGTCGTGCTGGCAACTCGGGATGCTCGCGCCAGGGCGACTTACGAAGCCCTAAGCGTGGACACCGAAG
TTGTTGCTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8369.54 Da        Isoelectric Point: 4.6750

>AT24996 WP_013472822.1 NC_014814:c4804727-4804488 [Mycolicibacterium gilvum Spyr1]
MEAVIDSGGRVVLPKQLRDALGLTPGTKVDISAYGGGLQIVPGGRTARLERDDDGRLVAQADTVVTDEMMFAIIDSGRR

Download         Length: 240 bp

>AT24996 NC_014814:c4804727-4804488 [Mycolicibacterium gilvum Spyr1]
ATGGAGGCTGTGATCGATTCCGGTGGTCGAGTGGTCCTGCCGAAGCAACTGCGGGACGCACTGGGTTTGACTCCCGGCAC
AAAAGTAGACATTTCTGCCTACGGCGGTGGGTTACAGATCGTTCCGGGCGGGCGAACCGCTCGACTTGAACGCGACGACG
ATGGTCGCCTCGTGGCGCAAGCCGACACCGTCGTCACCGACGAAATGATGTTCGCCATCATCGACTCGGGTCGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References