Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3464198..3464816 Replicon chromosome
Accession NZ_CP099912
Organism Escherichia albertii strain 105_1_LWG_A

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIY85_RS17240 Protein ID WP_001280991.1
Coordinates 3464598..3464816 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIY85_RS17235 Protein ID WP_000344798.1
Coordinates 3464198..3464572 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY85_RS17225 (3459278) 3459278..3460471 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIY85_RS17230 (3460494) 3460494..3463643 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIY85_RS17235 (3464198) 3464198..3464572 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIY85_RS17240 (3464598) 3464598..3464816 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIY85_RS17245 (3464993) 3464993..3465550 + 558 WP_025237467.1 maltose O-acetyltransferase -
NIY85_RS17250 (3465657) 3465657..3466127 + 471 WP_000136188.1 YlaC family protein -
NIY85_RS17255 (3466291) 3466291..3467841 + 1551 WP_256876460.1 EAL domain-containing protein -
NIY85_RS17260 (3467879) 3467879..3468232 - 354 WP_000878151.1 DUF1428 family protein -
NIY85_RS17270 (3468613) 3468613..3468924 + 312 WP_256876461.1 MGMT family protein -
NIY85_RS17275 (3468954) 3468954..3469526 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249957 WP_001280991.1 NZ_CP099912:3464598-3464816 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249957 WP_000344798.1 NZ_CP099912:3464198-3464572 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References