Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 883307..883958 Replicon chromosome
Accession NZ_CP099912
Organism Escherichia albertii strain 105_1_LWG_A

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag NIY85_RS04255 Protein ID WP_000244763.1
Coordinates 883554..883958 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NIY85_RS04250 Protein ID WP_000354046.1
Coordinates 883307..883573 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY85_RS04225 (879019) 879019..880452 - 1434 WP_256876629.1 6-phospho-beta-glucosidase BglA -
NIY85_RS04230 (880497) 880497..880808 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NIY85_RS04235 (880976) 880976..881635 + 660 WP_000250281.1 hemolysin III family protein -
NIY85_RS04240 (882075) 882075..883055 - 981 WP_025238421.1 tRNA-modifying protein YgfZ -
NIY85_RS04245 (883087) 883087..883317 + 231 WP_000181267.1 hypothetical protein -
NIY85_RS04250 (883307) 883307..883573 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NIY85_RS04255 (883554) 883554..883958 + 405 WP_000244763.1 protein YgfX Toxin
NIY85_RS04260 (883997) 883997..884518 - 522 WP_025238422.1 flavodoxin FldB -
NIY85_RS04265 (884630) 884630..885526 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NIY85_RS04270 (885551) 885551..886261 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIY85_RS04275 (886267) 886267..888000 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T249945 WP_000244763.1 NZ_CP099912:883554-883958 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT249945 WP_000354046.1 NZ_CP099912:883307-883573 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References