Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 138562..139174 Replicon chromosome
Accession NZ_CP099912
Organism Escherichia albertii strain 105_1_LWG_A

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NIY85_RS00610 Protein ID WP_000833473.1
Coordinates 138562..138747 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag NIY85_RS00615 Protein ID WP_000499744.1
Coordinates 138764..139174 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY85_RS00595 (134026) 134026..135321 + 1296 WP_025238096.1 Fic family protein -
NIY85_RS00600 (135429) 135429..136967 + 1539 WP_256876564.1 aldehyde dehydrogenase AldB -
NIY85_RS00605 (137008) 137008..138087 - 1080 WP_025238097.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
NIY85_RS00610 (138562) 138562..138747 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NIY85_RS00615 (138764) 138764..139174 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NIY85_RS00620 (139246) 139246..141210 - 1965 Protein_123 glycoside hydrolase family 127 protein -
NIY85_RS00625 (141221) 141221..142621 - 1401 WP_025238099.1 MFS transporter -
NIY85_RS00630 (142847) 142847..143662 + 816 WP_025238100.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T249943 WP_000833473.1 NZ_CP099912:138562-138747 [Escherichia albertii]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT249943 WP_000499744.1 NZ_CP099912:138764-139174 [Escherichia albertii]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References