Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 80501..81144 Replicon plasmid plas1
Accession NZ_CP099911
Organism Escherichia albertii strain 110_1_TBG_A

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NIY87_RS24085 Protein ID WP_256876211.1
Coordinates 80728..81144 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NIY87_RS24080 Protein ID WP_256876210.1
Coordinates 80501..80731 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY87_RS24055 (76574) 76574..77101 - 528 WP_000203268.1 colicin B immunity protein -
NIY87_RS24060 (77344) 77344..78159 + 816 WP_000449473.1 lipid II-degrading bacteriocin colicin M -
NIY87_RS24065 (78209) 78209..78562 - 354 WP_000864812.1 colicin M immunity protein -
NIY87_RS24070 (78735) 78735..79517 - 783 WP_021533580.1 site-specific integrase -
NIY87_RS24075 (79519) 79519..79932 - 414 WP_000465043.1 hypothetical protein -
NIY87_RS24080 (80501) 80501..80731 + 231 WP_256876210.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIY87_RS24085 (80728) 80728..81144 + 417 WP_256876211.1 type II toxin-antitoxin system VapC family toxin Toxin
NIY87_RS24090 (81284) 81284..82264 + 981 WP_256876212.1 hypothetical protein -
NIY87_RS24095 (82472) 82472..84043 - 1572 WP_256876213.1 ATP-binding protein -
NIY87_RS24100 (84362) 84362..84631 + 270 WP_256876214.1 hypothetical protein -
NIY87_RS24105 (84619) 84619..85215 + 597 WP_256876215.1 hypothetical protein -
NIY87_RS24110 (85752) 85752..86093 + 342 Protein_99 protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 1..89096 89096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.41 Da        Isoelectric Point: 6.7125

>T249942 WP_256876211.1 NZ_CP099911:80728-81144 [Escherichia albertii]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAISGHAIAAGAILVTNNTREFERVPGLILEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8678.80 Da        Isoelectric Point: 4.6017

>AT249942 WP_256876210.1 NZ_CP099911:80501-80731 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGGSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References