Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3542564..3543182 Replicon chromosome
Accession NZ_CP099910
Organism Escherichia albertii strain 110_1_TBG_A

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIY87_RS17375 Protein ID WP_001280991.1
Coordinates 3542964..3543182 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIY87_RS17370 Protein ID WP_000344798.1
Coordinates 3542564..3542938 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY87_RS17360 (3537644) 3537644..3538837 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIY87_RS17365 (3538860) 3538860..3542009 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIY87_RS17370 (3542564) 3542564..3542938 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIY87_RS17375 (3542964) 3542964..3543182 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIY87_RS17380 (3543359) 3543359..3543916 + 558 WP_000093561.1 maltose O-acetyltransferase -
NIY87_RS17385 (3544024) 3544024..3544494 + 471 WP_059224581.1 YlaC family protein -
NIY87_RS17390 (3544658) 3544658..3546208 + 1551 WP_256876043.1 EAL domain-containing protein -
NIY87_RS17395 (3546246) 3546246..3546599 - 354 WP_000878151.1 DUF1428 family protein -
NIY87_RS17405 (3546980) 3546980..3547291 + 312 WP_000409915.1 MGMT family protein -
NIY87_RS17410 (3547321) 3547321..3547893 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249930 WP_001280991.1 NZ_CP099910:3542964-3543182 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249930 WP_000344798.1 NZ_CP099910:3542564-3542938 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References