Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 41356..42140 | Replicon | chromosome |
| Accession | NC_014814 | ||
| Organism | Mycobacterium gilvum Spyr1 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | E6TGU5 |
| Locus tag | MSPYR1_RS00210 | Protein ID | WP_011891693.1 |
| Coordinates | 41356..41865 (-) | Length | 170 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | MSPYR1_RS00215 | Protein ID | WP_013470294.1 |
| Coordinates | 41862..42140 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MSPYR1_RS00175 | 37667..37936 | + | 270 | WP_041787495.1 | YdeI/OmpD-associated family protein | - |
| MSPYR1_RS00180 | 37941..38360 | - | 420 | WP_011891699.1 | ChaB family protein | - |
| MSPYR1_RS00185 | 38398..38610 | - | 213 | WP_013470293.1 | DUF3072 domain-containing protein | - |
| MSPYR1_RS00190 | 38706..39203 | + | 498 | WP_011891697.1 | PPOX class F420-dependent oxidoreductase | - |
| MSPYR1_RS00195 | 39210..40016 | - | 807 | WP_011891696.1 | thioesterase family protein | - |
| MSPYR1_RS00200 | 40045..40386 | - | 342 | WP_011891695.1 | N-acetyltransferase | - |
| MSPYR1_RS00205 | 40394..41359 | - | 966 | WP_011891694.1 | pirin family protein | - |
| MSPYR1_RS00210 | 41356..41865 | - | 510 | WP_011891693.1 | GNAT family N-acetyltransferase | Toxin |
| MSPYR1_RS00215 | 41862..42140 | - | 279 | WP_013470294.1 | DUF1778 domain-containing protein | Antitoxin |
| MSPYR1_RS00220 | 42151..42576 | - | 426 | WP_013470295.1 | EVE domain-containing protein | - |
| MSPYR1_RS00225 | 42638..43405 | - | 768 | WP_011891690.1 | type I methionyl aminopeptidase | - |
| MSPYR1_RS00230 | 43495..43761 | + | 267 | WP_011891689.1 | helix-turn-helix domain-containing protein | - |
| MSPYR1_RS00235 | 43791..44060 | + | 270 | WP_011891688.1 | DivIVA domain-containing protein | - |
| MSPYR1_RS00240 | 44053..45294 | + | 1242 | Protein_44 | biotin carboxylase | - |
| MSPYR1_RS00245 | 45429..46733 | + | 1305 | WP_006242318.1 | IS256 family transposase | - |
| MSPYR1_RS00250 | 46767..47090 | + | 324 | Protein_46 | biotin carboxylase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 45429..46733 | 1304 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 170 a.a. Molecular weight: 18505.11 Da Isoelectric Point: 7.0514
>T24993 WP_011891693.1 NC_014814:c41865-41356 [Mycolicibacterium gilvum Spyr1]
MSGYTAPRPISELDEVDQFDSGEPSLDEYLKRRALANHAEGASRCFVTCREGRVVGFYALASGAVERAATPGRMRRNMPD
PVPVILLSRLAVDRTEQRQGLGAHLLRDAIIRAVAAAQFVGVRALLVHAVHEQAREFYAHFNFEPSPTDPLHLLLLAPPG
RSVPPTVEA
MSGYTAPRPISELDEVDQFDSGEPSLDEYLKRRALANHAEGASRCFVTCREGRVVGFYALASGAVERAATPGRMRRNMPD
PVPVILLSRLAVDRTEQRQGLGAHLLRDAIIRAVAAAQFVGVRALLVHAVHEQAREFYAHFNFEPSPTDPLHLLLLAPPG
RSVPPTVEA
Download Length: 510 bp
>T24993 NC_014814:c41865-41356 [Mycolicibacterium gilvum Spyr1]
ATGAGCGGCTACACCGCTCCCCGGCCGATCAGCGAGTTGGACGAAGTAGACCAGTTCGACAGTGGTGAGCCCAGCCTGGA
CGAGTATCTGAAGCGCCGCGCACTGGCAAACCATGCCGAAGGCGCGTCCCGCTGTTTCGTGACCTGCCGAGAGGGGCGCG
TCGTCGGGTTCTACGCGCTGGCCTCCGGCGCTGTGGAACGCGCCGCCACGCCGGGACGGATGCGGCGCAACATGCCCGAC
CCGGTGCCGGTCATTCTGTTGTCACGGTTGGCCGTCGATCGCACGGAGCAGAGGCAGGGGTTGGGTGCCCACCTGCTGCG
GGACGCGATCATCCGGGCGGTGGCAGCCGCTCAGTTCGTCGGCGTCAGGGCGCTCCTCGTGCACGCCGTCCATGAACAGG
CACGCGAGTTCTACGCGCACTTCAACTTCGAGCCATCGCCGACGGACCCCCTGCATCTCCTTTTGTTGGCACCACCCGGC
CGCTCGGTACCTCCTACTGTGGAGGCATGA
ATGAGCGGCTACACCGCTCCCCGGCCGATCAGCGAGTTGGACGAAGTAGACCAGTTCGACAGTGGTGAGCCCAGCCTGGA
CGAGTATCTGAAGCGCCGCGCACTGGCAAACCATGCCGAAGGCGCGTCCCGCTGTTTCGTGACCTGCCGAGAGGGGCGCG
TCGTCGGGTTCTACGCGCTGGCCTCCGGCGCTGTGGAACGCGCCGCCACGCCGGGACGGATGCGGCGCAACATGCCCGAC
CCGGTGCCGGTCATTCTGTTGTCACGGTTGGCCGTCGATCGCACGGAGCAGAGGCAGGGGTTGGGTGCCCACCTGCTGCG
GGACGCGATCATCCGGGCGGTGGCAGCCGCTCAGTTCGTCGGCGTCAGGGCGCTCCTCGTGCACGCCGTCCATGAACAGG
CACGCGAGTTCTACGCGCACTTCAACTTCGAGCCATCGCCGACGGACCCCCTGCATCTCCTTTTGTTGGCACCACCCGGC
CGCTCGGTACCTCCTACTGTGGAGGCATGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10200.71 Da Isoelectric Point: 5.1425
>AT24993 WP_013470294.1 NC_014814:c42140-41862 [Mycolicibacterium gilvum Spyr1]
MEAVAAKSERFAVRLTAEQDALIRRAAEVEGTDLTNFTLTATLAHAREVLADRRLFMLGEPAWSEFLSVLDRPVSPKPRL
AKLFAEPSIFDG
MEAVAAKSERFAVRLTAEQDALIRRAAEVEGTDLTNFTLTATLAHAREVLADRRLFMLGEPAWSEFLSVLDRPVSPKPRL
AKLFAEPSIFDG
Download Length: 279 bp
>AT24993 NC_014814:c42140-41862 [Mycolicibacterium gilvum Spyr1]
ATGGAGGCCGTGGCTGCCAAATCAGAGCGATTCGCCGTGCGCCTGACCGCGGAGCAGGACGCCCTCATTCGCCGTGCCGC
CGAAGTCGAAGGGACCGACCTCACCAACTTCACGCTTACTGCGACGCTGGCCCACGCCCGCGAGGTACTCGCCGACCGAC
GGTTGTTCATGCTCGGCGAGCCGGCATGGTCGGAGTTCCTGTCCGTATTGGACCGTCCCGTGTCCCCCAAGCCGCGGTTG
GCGAAGTTGTTCGCGGAGCCCTCGATCTTCGACGGATGA
ATGGAGGCCGTGGCTGCCAAATCAGAGCGATTCGCCGTGCGCCTGACCGCGGAGCAGGACGCCCTCATTCGCCGTGCCGC
CGAAGTCGAAGGGACCGACCTCACCAACTTCACGCTTACTGCGACGCTGGCCCACGCCCGCGAGGTACTCGCCGACCGAC
GGTTGTTCATGCTCGGCGAGCCGGCATGGTCGGAGTTCCTGTCCGTATTGGACCGTCCCGTGTCCCCCAAGCCGCGGTTG
GCGAAGTTGTTCGCGGAGCCCTCGATCTTCGACGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|