Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2493857..2494461 Replicon chromosome
Accession NZ_CP099910
Organism Escherichia albertii strain 110_1_TBG_A

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NIY87_RS12385 Protein ID WP_059225486.1
Coordinates 2494075..2494461 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag NIY87_RS12380 Protein ID WP_001195490.1
Coordinates 2493857..2494078 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY87_RS12365 (2490107) 2490107..2491558 + 1452 WP_000854601.1 tagaturonate reductase -
NIY87_RS12370 (2491763) 2491763..2492677 + 915 WP_024164792.1 bestrophin family protein -
NIY87_RS12375 (2492681) 2492681..2493439 - 759 WP_233991857.1 trans-aconitate 2-methyltransferase -
NIY87_RS12380 (2493857) 2493857..2494078 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NIY87_RS12385 (2494075) 2494075..2494461 + 387 WP_059225486.1 type II toxin-antitoxin system death-on-curing family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-110)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14452.45 Da        Isoelectric Point: 7.3228

>T249926 WP_059225486.1 NZ_CP099910:2494075-2494461 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRICDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT249926 WP_001195490.1 NZ_CP099910:2493857-2494078 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References