Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1962308..1962898 Replicon chromosome
Accession NZ_CP099910
Organism Escherichia albertii strain 110_1_TBG_A

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NIY87_RS09490 Protein ID WP_059225520.1
Coordinates 1962566..1962898 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NIY87_RS09485 Protein ID WP_059225519.1
Coordinates 1962308..1962565 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY87_RS09475 (1961288) 1961288..1961758 + 471 WP_059225518.1 hypothetical protein -
NIY87_RS09480 (1961755) 1961755..1961960 + 206 Protein_1852 helix-turn-helix domain-containing protein -
NIY87_RS09485 (1962308) 1962308..1962565 + 258 WP_059225519.1 hypothetical protein Antitoxin
NIY87_RS09490 (1962566) 1962566..1962898 + 333 WP_059225520.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NIY87_RS09495 (1963011) 1963011..1963388 + 378 WP_161537949.1 hypothetical protein -
NIY87_RS09500 (1963706) 1963706..1964590 + 885 WP_059225521.1 integrase domain-containing protein -
NIY87_RS09505 (1964686) 1964686..1964973 - 288 WP_059225522.1 hypothetical protein -
NIY87_RS09510 (1965932) 1965932..1967194 - 1263 WP_059225524.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11777.59 Da        Isoelectric Point: 8.0291

>T249920 WP_059225520.1 NZ_CP099910:1962566-1962898 [Escherichia albertii]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSPASFNEVTRLPVIVPVTSGGQFARSAGFAVSLEGAGTKTTGIIRCDQPRTI
DMGARNGKRLERIPDGIINEVLARLETILA

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9314.80 Da        Isoelectric Point: 4.4488

>AT249920 WP_059225519.1 NZ_CP099910:1962308-1962565 [Escherichia albertii]
MYTTRLKKVGGSVMLAVPPAVLKTLALLPDSEVGVTIDNGCLIIEPQKRPRYSLAELLAQCDPHEEISDEEREWIDAPAA
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References