Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 188229..188857 Replicon plasmid pMSPYR101
Accession NC_014811
Organism Mycobacterium gilvum Spyr1

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J6VVW2
Locus tag MSPYR1_RS27105 Protein ID WP_041789295.1
Coordinates 188229..188639 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID E6TPS1
Locus tag MSPYR1_RS27110 Protein ID WP_013470249.1
Coordinates 188630..188857 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSPYR1_RS27090 183514..185463 + 1950 WP_013470245.1 hypothetical protein -
MSPYR1_RS27095 185636..186622 + 987 WP_013470246.1 non-homologous end-joining DNA ligase -
MSPYR1_RS27100 186623..188182 - 1560 WP_013470247.1 serine/threonine protein kinase -
MSPYR1_RS27105 188229..188639 - 411 WP_041789295.1 ribonuclease Toxin
MSPYR1_RS27110 188630..188857 - 228 WP_013470249.1 hypothetical protein Antitoxin
MSPYR1_RS27115 189003..189959 + 957 WP_013470250.1 DUF4226 domain-containing protein -
MSPYR1_RS28140 189991..190416 - 426 WP_081460779.1 hypothetical protein -
MSPYR1_RS27125 190343..190717 + 375 WP_158022686.1 hypothetical protein -
MSPYR1_RS27130 190796..191500 - 705 WP_013470253.1 hypothetical protein -
MSPYR1_RS27135 191957..193156 + 1200 WP_013470254.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fbpA 1..211864 211864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14680.87 Da        Isoelectric Point: 4.8232

>T24992 WP_041789295.1 NC_014811:c188639-188229 [Mycolicibacterium gilvum Spyr1]
VAVTNWLIDKSAYTQLVASPDAQAWVERIERGLVRMSTVTRLQIGYSFRNGSQARSESGAPPLALMPLEYLTPAAEDRAV
GVQLQLADRGLHRAPAIPDLLVAAVAEMAGLTVLALDTDFDLIAQVTGQAVERLRL

Download         Length: 411 bp

>T24992 NC_014811:c188639-188229 [Mycolicibacterium gilvum Spyr1]
GTGGCGGTGACCAACTGGCTCATCGACAAGTCGGCCTACACGCAACTGGTGGCCTCCCCAGACGCCCAGGCCTGGGTCGA
GCGCATCGAACGCGGTCTCGTGCGCATGAGCACCGTCACCCGCCTACAGATCGGCTACTCGTTCCGGAACGGATCGCAGG
CCCGCAGCGAATCAGGCGCACCGCCGCTGGCATTGATGCCGCTCGAGTACCTGACCCCAGCAGCCGAGGACCGCGCCGTG
GGCGTGCAGCTCCAGCTGGCCGACCGTGGGCTGCACCGCGCCCCGGCGATCCCGGATCTGCTGGTGGCTGCTGTCGCTGA
GATGGCCGGCCTCACCGTGCTTGCTCTCGACACGGACTTCGACCTGATCGCGCAAGTCACCGGGCAAGCCGTCGAACGGC
TCCGCCTATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8110.02 Da        Isoelectric Point: 4.3664

>AT24992 WP_013470249.1 NC_014811:c188857-188630 [Mycolicibacterium gilvum Spyr1]
MGDVLIRGLSDAAIARIDADAAARGVSRQEYLRTRFETEGSVSAPTRTMTVDDLRRAAAAATDLDDPDIMDAAWR

Download         Length: 228 bp

>AT24992 NC_014811:c188857-188630 [Mycolicibacterium gilvum Spyr1]
ATGGGCGATGTGCTGATCCGCGGACTGTCCGACGCGGCGATCGCGCGTATCGACGCCGACGCCGCCGCCCGCGGTGTCTC
GCGCCAAGAGTATCTGCGAACCAGATTCGAGACCGAAGGTTCAGTGAGCGCCCCCACGCGGACCATGACTGTCGACGATC
TACGCCGCGCCGCCGCGGCGGCCACCGACCTCGACGATCCCGACATCATGGACGCCGCGTGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J6VVW2

Antitoxin

Source ID Structure
AlphaFold DB A0A1P8XLG4

References