Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 76508..77109 Replicon plasmid plas2
Accession NZ_CP099909
Organism Escherichia albertii strain 112_1_EW_A

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag NIY89_RS24560 Protein ID WP_001216045.1
Coordinates 76729..77109 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag NIY89_RS24555 Protein ID WP_001190712.1
Coordinates 76508..76729 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY89_RS24545 (NIY89_24515) 73534..74772 - 1239 WP_256909406.1 restriction endonuclease subunit S -
NIY89_RS24550 (NIY89_24520) 74769..76325 - 1557 WP_073511017.1 type I restriction-modification system subunit M -
NIY89_RS24555 (NIY89_24525) 76508..76729 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NIY89_RS24560 (NIY89_24530) 76729..77109 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NIY89_RS24565 (NIY89_24535) 77114..77293 + 180 WP_000113019.1 hypothetical protein -
NIY89_RS24570 (NIY89_24540) 77321..78364 + 1044 WP_256876191.1 DUF968 domain-containing protein -
NIY89_RS24575 (NIY89_24545) 78453..78905 + 453 WP_001326849.1 late promoter-activating protein -
NIY89_RS24580 (NIY89_24550) 78992..80185 + 1194 WP_000219618.1 hypothetical protein -
NIY89_RS24585 (NIY89_24555) 80185..81669 + 1485 WP_000124159.1 hypothetical protein -
NIY89_RS24590 (NIY89_24560) 81753..81983 + 231 Protein_81 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97238 97238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T249915 WP_001216045.1 NZ_CP099909:76729-77109 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT249915 WP_001190712.1 NZ_CP099909:76508-76729 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References